Tadalafil Drug Information

Breast-feeding—Tadalafil is for use in men only. It is not known if tadalafil passes into human breast milk.

Children—Tadalafil is not for use in children.

Older adults—This medicine has been tested in a limited number of patients 65 years of age or older and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Other medicines—Although some medicines should not be used together at all, there are cases when 2 different medicines maybe used together even if an interaction might occur. In such cases, your doctor may advise you to change the dose, or other precautions may be required. When you are taking tadalafil, it is especially important that your doctor and pharmacist know if you are taking any of the following:

• Erectile dysfunction medicines—These medicines should not be used at the same time as tadalafil because the safety of using these medicines in combination has not been proven.

• Nitrates (medicine used to treat chest pain [e.g., nitroglycerin])—These medicines should not be used at the same time as tadalafil because they can cause very low blood pressure and serious side effects.

• Alcoholic beverages—Drinking alcohol can cause an increased chance of some side effects.

• Alpha blockers, other than tamsulosin 0.4 mg taken once a day (medicine for high blood pressure)—These medicines should be used with caution when taken at the same time as tadalafil because they can cause very low blood pressure and serious side effects.

• Erythromycin (e.g., Apo-erythro) or
• Itraconazole (e.g., Sporanox) or
• Ketoconazole (e.g., Nizoral) or
• Grapefruit juice or
• Ritonavir (e.g., Norvir) or
• Saquinavir (e.g., Fortovase, Invirase)—These medicines or food may increase your chance of getting side effects.

Other medical problems—The existence of other medical problems may influence the use of /tadalafil. You should tell your doctor if you have any other medical problems, in particular::

• Age greater than 50 years or
• Coronary artery disease or
• Diabetes or
• Hyperlipidemia (excess of lipids in the blood) or
• Hypertension (high blood pressure) or
• Low cup to disc ratio (“crowded disc”) or
• Smoking—These conditions may increase risk for a serious eye problem called NAION.

• Angina (reoccurring chest pain) or
• Arrhythmia (irregular heartbeat) or
• Hypotension (low blood pressure) or
• Hypertension (high blood pressure) or
• Stroke (recent history of) or
• Heart attack (within the last 3 months) or
• Heart failure (within the last 6 months) or
• Retinal disorders (rare hereditary eye problem)—Tadalafil has not been studied in patients with these medical conditions and should not be used.

• Kidney disease (severe)—Tadalafil should be used with caution in these patients and a lower dose may be needed.

• Liver disease—Tadalafil should not be used in patients with serious liver disease; in patients with less serious liver disease, tadalafil should be used with caution and a lower dose may be needed.

• Abnormal penis, including curved penis and birth defects of the penis—Chance of problems occurring may be increased and this medicine should be used with caution in these patients

• Bleeding disorders or
• Stomach ulcers—Chance of problems occurring may be increased; it is not known if the medicine is safe for use in these patients.

• Heart disease, underlying—Chance of low blood pressure occurring is greater; tadalafil should be used carefully in these patients.

• Heart blood flow problems—These conditions may cause you to be more sensitive to tadalafil.

• Sickle-cell anemia (blood disorder) or
• Bone marrow cancer or
• Leukemia (blood related cancer)—Tadalafil should be used with caution in these patients as problems with prolonged erection of the penis may occur.

• NAION (serious eye condition) in one or both eyes, previously—May increase your chance of getting NAION again.

Proper Use of This Medicine

Special patient directions come with tadalafil. Read the directions carefully before you start using tadalafil and each time you get a refill of your medicine .

Use tadalafil exactly as directed by your doctor . Do not use more of it and do not use it more often than your doctor ordered. If too much is used, the chance of side effects or other problems is increased.

Dosing—The dose of tadalafil will vary for different patients. Adhere to the orders of your doctor or the instructions on the label . The information below includes only the average doses of tadalafil. If your dose differs, you should not change it unless your doctor tells you to do so.

• For oral dosage form (tablets):
  • For treatment of erectile dysfunction:
    • Adults—10 mg as a single dose no more than once a day, taken before you think sexual activity may occur. The ability to have sexual activity may be improved up to 36 hours after taking tadalafil when compared to placebo (sugar pill). If needed, your doctor may change your dose.

Storage—To store this medicine properly, follow the instructions below:

• Keep out of the reach of children.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Keep the medicine from freezing. Do not refrigerate.
• Do not keep outdated medicine or medicine no longer needed. Ask your health care professional how you should dispose of any medicine you do not use. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

Tadalafil has not been studied with other medicines used for treatment of erectile dysfunction. Using them together is not recommended .

It is important that you tell all of your healthcare providers that you take tadalafil . If you need emergency medical care for a heart problem, it is important that your healthcare provider knows when you last took tadalafil.

If you experience a prolonged or painful erection for 4 hours or more, contact your doctor immediately. This condition may require prompt medical treatment to prevent serious and permanent damage to your penis.

This medicine does not protect you against sexually transmitted diseases. Use protective measures and ask your doctor if you have any questions about this.

It is important to tell your doctor about any heart problems you may have now or may have had in the past. This medicine can cause serious side effects in patients with heart problems.

Do not drink alcohol to excess (for example, 5 glasses of wine or 5 shots of whiskey) when taking tadalafil. When taken in excess alcohol can increase your chances of getting a headache or getting dizzy, increasing your heart rate, or lowering your blood pressure.

If you experience sudden loss of vision in one or both eyes, stop using tadalafil and contact your doctor immediately.

Side Effects of This Medicine

Alongside with its expected effects, any medicine may be the cause of some unwanted effects. Although not all of these side effects may happen, if they do happen they may require medical attention.

Other side effects not mentioned above may also happen in some patients. If you notice any other effects, tell your doctor about it.

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